Ethanol is mainly absorbed by the small intestine and, to a lesser degree, through the stomach. Gastric alcohol dehydrogenase (ADH) initiates alcohol metabolism. Three enzyme systems account for metabolism of alcohol in the liver. These include cytosolic ADH, the microsomal-oxidizing system (MEOS), and peroxisomal catalase. The majority of ethanol oxidation occurs via ADH to form acetaldehyde, which is a highly reactive molecule that may have multiple effects. Ultimately, acetaldehyde is metabolized to acetate by aldehyde dehydrogenase (ALDH). Intake of ethanol increases intracellular accumulation of triglycerides by increasing fatty acid uptake and by reducing fatty acid oxidation and lipoprotein secretion. Protein synthesis, glycosylation, and secretion are impaired. Oxidative damage to hepatocyte membranes occurs due to the formation of reactive oxygen species; acetaldehyde is a highly reactive molecule that combines with proteins to form protein-acetaldehyde adducts. These adducts may interfere with specific enzyme activities, including microtubular formation and hepatic protein trafficking. With acetaldehyde-mediated hepatocyte damage, certain reactive oxygen species can result in Kupffer cell activation. As a result, profibrogenic cytokines are produced that initiate and perpetuate stellate cell activation, with the resultant production of excess collagen and extracellular matrix. Connective tissue appears in both periportal and pericentral zones and eventually connects portal triads with central veins forming regenerative nodules. Hepatocyte loss occurs, and with increased collagen production and deposition, together with continuing hepatocyte destruction, the liver contracts and shrinks in size. This process generally takes from years to decades to occur and requires repeated insults
Servlet | Droplet |
Servlet is a java class which extends HttpServlet | Droplet is java class which extends DynamoServlet (customized in atg) |
Servlet extends HttpServlet extends GenericServlet implements javax.servlet.Servlet | Droplet extends Dynamo Servlet extends HttpServletService extends ServletService implements javax.servlet.Servlet |
Servlet can be invoked from a jsp giving the servlet path and name <jsp:forward page="/MyServlet"/> or <form method="POST" action="/ProfileSyncService"> | Droplet can be embedded in jsp as <dsp:droplet name="sampleDroplet"> to fetch the information |
Not applicable. | One or more droplets can be present in a jsp. Nested droplets are also applicable. |
Servlet is used to submit data, it acts as a controller. It is not used to put data. | Droplet is used to render or put data in the db |
