chlorthalidone for Females ????

Cardionice feels happy to bring out a less know drug but with good efficacy and potency in the treatment of hypertension and edema.

Chlorthalidone-
An oral diuretic
prolonged action (48–72 hours) and low toxicity.
Excreted unchanged by the kidneys.
Onset of Diuretic effect - 2.6 hours and continues for up to 72 hours.
Mean half-life following a 50 to 200 mg dose is 40 hours. In the first order of absorption, the elimination half-life is 53 hours following a 50 mg dose, and 60 hours following a 100 mg dose. Approximately 75 percent of the drug is bound to plasma proteins, 58 percent of the drug being bound to albumin. This is caused by an increased affinity of the drug to erythrocyte carbonic anhydrase.


The drug produces copious diuresis with greatly increased excretion of sodium and chloride. At maximal therapeutic dosage, Chlorthalidone is approximately equal in its diuretic effect to comparable maximal therapeutic doses of benzothiadiazine diuretics. The site of action appears to be the cortical diluting segment of the ascending limb of Henle's loop of the nephron.

 

Hypertension


Initiation:
a single daily dose of 25 mg. If the response is insufficient , dosage may be increased to a single daily dose of 50 mg. If additional control is required, the dosage of Chlorthalidone may be increased to 100 mg once daily or a second antihypertensive drug (step 2 therapy) may be added. Dosage above 100 mg daily usually does not increase effectiveness. Increases in serum uric acid and decreases in serum potassium are dose-related over the 25 to 100 mg/day range.


Maintenance: Maintenance doses may be lower than initial doses and should be adjusted according to individual patient response. Effectiveness is well sustained during continued use.

Edema


Initiation: Adults, initially 50 to 100 mg daily, or 100 mg on alternate days. Some patients may require 150 to 200 mg at these intervals or up to 200 mg daily. Dosages above this level, however, do not usually produce a greater response.


Maintenance: Maintenance doses may often be lower than initial doses and should be adjusted according to individual patient response. Effectiveness is well sustained during continued use.

Think about a menopaused,hypertensive women who is prone for osteoporosis.what drug can kill birds with one arrow???------is the drug what we are discussing as above-chlorthalidone.

It reduces the calcium excretion in kidneys.hence it conserves calcium and helps in preventing osteoporosis.






Nice?????has to be!!!!!!!!!!!!!!!!