Being a Male-Is it a Curse?

Cardionice greetings folks;

Did we ever wonder how females are lucky?,did we ever wonder how most of cases of hypertension and CAD are males?,Did God curse the male society for its dominance over females?. Well ! if any CAD male prays god,its right time to ask why god throw the bad stick on them, while leaving counterpart.
Reason being, 

Male Gene Linked To Coronary Artery Disease Risk

Study- To identify the role of the Y chromosome in coronary artery disease in the context of this sexual inequity

Sample size-3233 biologically unrelated British men from 3 studies

Study type-Cohort, (done by the British Heart Foundation Family Heart Study (BHF-FHS), West of Scotland Coronary Prevention Study (WOSCOPS), and Cardiogenics Study)

Method- Each Y chromosome was tracked back into one of 13 ancient lineages defined as haplogroups

Findings:

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Nine haplogroups were identified, in that, two groups (R1b1b2 and I) accounted for roughly 90% of the Y chromosome variants among British men. 

Carriers of haplogroup I (15% to 20% of the British male population) had about a 50% higher age-adjusted risk of CAD than did men with other Y chromosome lineages in BHF-FHS,WOSCOPS, and joint analysis of both populations.

The association between haplogroup I and increased risk of CAD was independent of traditional cardiovascular and socioeconomic risk factors, such as age, body-mass index, blood pressure, lipids, diabetes, smoking, alcohol consumption, socioeconomic status, or circulating concentrations of C-reactive protein.


Explanation:
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Men with haplogroup I showed downregulation of adaptive immunity as well as upregulation of inflammatory response pathways in their macrophages (immune system cells) compared with carriers of other Y chromosome types. 


These data show that predisposition to CAD in men might, at least in part, be determined by the paternal lineage of their Y chromosome and that this effect on risk of coronary artery disease is most likely mediated through the immune response

Study published in-the lancet [link]

Author comments:

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"Our study is the first to evaluate associations between main European Y chromosome lineages and CAD as well as its underlying risk factors...[it has] revealed that the Y chromosome might have a magnified effect on men beyond sex determination despite the small number of genes it harbours in the human genome.

Future resequencing efforts and functional experiments will be needed to identify the causative variants underlying the increased susceptibility to coronary artery disease in carriers of haplogroup I and to decipher complex interplay between human Y chromosome, immunity, and cardiovascular disease."

Dr Virginia Miller, Mayo Clinic, Rochester, MN, USA said:

"Avenues for future research should include exploration of potential interconnections among pathways relating immunity to other forms of cardiovascular disease, such as those identified for various cardiomyopathies.


Finally, it would be interesting to examine whether existing algorithms assessing individual risk of coronary artery disease for men could be improved by changing the question 'Did your mother or father have a heart attack before age 60?' to 'Did your father have a heart attack before the age of 60?' Both sex and family do matter in inheritance of coronary artery disease." 

 Finally,while nagging God regarding the above, also do thank him for this wonderfull life he bestowed.