Mitotane and infertility

Men with classic 21-hydroxylase deficiency are at risk for infertility.

The mechanisms are complex and involve three factors:

gonadotropin inhibition due to the excessive secretion of progestin by the adrenal glands,

obstruction of the rete testis, and

destruction of the testes by testicular adrenal rest tumors.

Antisecretory and antitumoral activities of mitotane, a drug that induces “chemical adrenalectomy restore the fertility of a man with both 21-hydroxylase deficiency and azoospermia.

The 21-hydroxylase deficiency was suspected at birth because of salt wasting and was confirmed by elevated serum levels of 17-hydroxyprogesterone and molecular analysis of CYP21A2.

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hashCode and equals

Lets understand with a small example where and why hashCode and equals are used.

Java.lang.Object has methods called hasCode() and equals(). These methods play a significant role in the real time application. However its use is not always common to all applications. In some case these methods are overridden to perform certain purpose. I will explain you some concept of these methods and why it becomes necessary to override these methods.

The Frey's.....

Frey....
2 terminologies in medicine.

The henle's...

Loop of henle, between PCT and DCT -kidneys ,
The other Henle's anatomical & pathological findings are:

Potter syndrome

Features :
POTTER:

Success secrets

"Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time"

On the “powerful blend of instruction, encouragement, and constant practice

“The trick to creativity … is to identify your own peculiar talent and then to settle down to work with it for a good long time ”

Red chilli onion chutney

Shallots 10
Garlic 10small

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