Non antibiotic approach to UTI treatment

Most important step in causing uti bu uropathogenic Escherichia coli, is the "adhesion" of bacteria to urothelial cells.

This attachment is mediated by "FimH", a mannose-binding adhesin, which is expressed on the bacterial surface.

To date, UTIs are mainly treated with antibiotics, leading to the ubiquitous problem of increasing resistance against most of the currently available antimicrobials. Therefore, new treatment strategies are urgently needed, avoiding selection pressure and thereby implying a reduced risk of resistance.

A new class of highly active antimicrobials, anti adhesive molecule targeting the virulence factor FimH - indolinylphenyl mannoside

When it was administered in a mouse model at the low dosage of 1 mg/kg (corresponding to approximately 25 μg/mouse), the minimal therapeutic concentration to prevent UTI was maintained for more than 8 h. In a treatment study, the colony-forming units in the bladder could be reduced by almost 4 orders of magnitude, comparable to the standard antibiotic treatment with ciprofloxacin (8 mg/kg, sc).

So with the help of this novel anti adhesive molecule UTIs can be managed very simply without antibiotics.

Q: What are the causative organisms of bacterial meningitis?

Haemophilus influenzae, which used to be the most common cause of the disease in infants and young children before the HiB vaccine was introduced.

Listeria monocytogenes can infect people of any age, but pregnant women, very young children, and the elderly are at most risk. L. monocytogenes can be acquired through contaminated foods.

Neisseria meningitidis is highly contagious and causes meningococcal meningitis. This form is commonly found in children and young adults, including college students living in dorms.

Staphylococcus aureus may present itself after head trauma or brain surgery

Streptococcus pneumoniae, the most common cause of bacterial meningitis in children, may appear along with pneumonia, an ear infection, or a sinus infection

Q:Why patient needs to be in supine position after a spinal procedure?

A: Because of spinal headache which is due to dural drag. Dura is the pain sensitive part of the whole nervous system. So after a spinal procedure due to the loss of CSF dura gets pulled down just like pulling down of cloth in umbrella while closing it, but it's very minimal drag that is limited to just headache

Dew 4:a single pill!

A new pill to treat HIV infection that combines four medicines and only has to be taken once a day was approved by the U.S. Food and Drug Administration.

Stribild
which will be marketed by maker Gilead Sciences, contains the HIV drugs elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate. It will be prescribed to people who have never been treated for HIV infection, the agency said in a statement. Two of the drugs, elvitegravir and cobicistat, are new, the FDA noted. Elvitegravir interferes with one of the enzymes that HIV needs to multiply, while cobicistat inhibits an enzyme that metabolizes certain HIV drugs and so prolongs the effect of elvitegravir.

The combination of emtricitabine and tenofovir disoproxil fumarate is already marketed as Truvada, and they work in concert to block another enzyme that HIV needs to replicate.

dew 5: h2o2 potential!

Q:Is it safe to use hydrogen peroxidein cleaning dirty wounds?

A:Yes, but it is not advisable now a days because Peroxide is a solution made up of hydrogen and oxygen. It is a strong oxidizer and can be used as a cleaning agent and to prevent infections. When used topically, this antiseptic foams due to the enzyme catalase. As the catalase comes in contact with the skin it turns the hydrogen peroxide into water and oxygen gas.

 

 According to health experts at the Swedish Medical Center in Colorado, hydrogen peroxide contains too much oxygen for the blood leading to potential issues.  When your skin absorbs hydrogen peroxide, it can reduce the amount of fibroblasts, a particular cell that is imperative for cleaning and repairing damaged tissue

 

 http://www.medicaldaily.com/articles/11831/20120830/the-dangers-of-peroxide.htm#zr2duG06mcuqzeiV.99